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Spatial and functional organization of mitochondrial protein network.

ABSTRACT: Characterizing the spatial organization of the human mitochondrial proteome will enhance our understanding of mitochondrial functions at the molecular level and provide key insight into protein-disease associations. However, the sub-organellar location and possible association with mitochondrial diseases are not annotated for most mitochondrial proteins. Here, we characterized the functional and spatial organization of mitochondrial proteins by assessing their position in the Mitochondrial Protein Functional (MPF) network. Network position was assigned to the MPF network and facilitated the determination of sub-organellar location and functional organization of mitochondrial proteins. Moreover, network position successfully identified candidate disease genes of several mitochondrial disorders. Thus, our data support the use of network position as a novel method to explore the molecular function and pathogenesis of mitochondrial proteins.

SUBMITTER: Yang JS

PROVIDER: S-EPMC3590558 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Spatial and functional organization of mitochondrial protein network.

Yang Jae-Seong JS Kim Jinho J Park Solip S Jeon Jouhyun J Shin Young-Eun YE Kim Sanguk S

Scientific reports 20130101

Characterizing the spatial organization of the human mitochondrial proteome will enhance our understanding of mitochondrial functions at the molecular level and provide key insight into protein-disease associations. However, the sub-organellar location and possible association with mitochondrial diseases are not annotated for most mitochondrial proteins. Here, we characterized the functional and spatial organization of mitochondrial proteins by assessing their position in the Mitochondrial Prote ...[more]

PMID: 23466738

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