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Heparin and carboxymethylchitosan metal nanoparticles: an evaluation of their cytotoxicity.

ABSTRACT: In the search for noninvasive diagnostic techniques and new therapies, "nanosystems", which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics.

SUBMITTER: Bava A

PROVIDER: S-EPMC3590581 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Heparin and carboxymethylchitosan metal nanoparticles: an evaluation of their cytotoxicity.

Bava Adriana A Cappellini Francesca F Pedretti Elisa E Rossi Federica F Caruso Enrico E Vismara Elena E Chiriva-Internati Maurizio M Bernardini Giovanni G Gornati Rosalba R

BioMed research international 20130218

In the search for noninvasive diagnostic techniques and new therapies, "nanosystems", which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our r ...[more]

PMID: 23509708

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