Dataset Information

Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population.

ABSTRACT: The association between polymorphisms of ?-adducin (ADD1) gene and essential hypertension is still unclear. Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population. Blood samples and information including body mass index (BMI), smoking habit, and alcohol abuse were collected. Meanwhile, total cholesterol, high density lipoprotein, triglyceride were measured by automatic biochemistry analyzer. All 6 tag single nucleotide polymorphisms (tagSNPs) within ADD1 gene were genotyped by SNPstream genotyping system. Multifactor dimensionality reduction (MDR) was used to identify the interactions among the SNPs and the non-genetic factors. Results showed that plasma triglyceride, total cholesterol, and BMI were significantly higher in the hypertensive group than in the control group. Result from genotyping indicated that rs4963 was significantly associated with essential hypertension. After stratification by gender, rs4963 was associated with essential hypertension only in males. MDR analysis indicated that interaction among BMI, rs4963, and rs16843452 were involved in susceptibility of hypertension. The present study indicated that rs4963 within ADD1 gene was associated with essential hypertension in Chinese population, which might be related to altered exonic splicing and disrupted gene regulation.

SUBMITTER: Zhang LN

PROVIDER: S-EPMC3591139 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population.

Zhang Li-na LN Ji Lin-dan LD Fei Li-juan LJ Yuan Fang F Zhang Yue-miao YM Xu Jin J

BioMed research international 20121220

The association between polymorphisms of α-adducin (ADD1) gene and essential hypertension is still unclear. Thus, we carried out a case-control study and an interaction analysis to test whether ADD1 is a common candidate gene for hypertension in the Chinese population. Blood samples and information including body mass index (BMI), smoking habit, and alcohol abuse were collected. Meanwhile, total cholesterol, high density lipoprotein, triglyceride were measured by automatic biochemistry analyzer. ...[more]

PMID: 23509723

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Project description:BACKGROUND:To assess the association of the interaction between the rs9619311 and rs402007 polymorphisms and smoking with essential hypertension (EH) in a Chinese Han population. METHOD:Peripheral blood samples were extracted from 422 EH patients and 280 normotensive (NT) patients in a Chinese Han population. A whole blood genomic DNA extraction kit was used to extract genomic DNA from the blood samples. Polymerase chain reaction restriction fragment length polymorphism was used to detect the rs402007 polymorphism of a disintegrin and metalloproteinase with thrombospondin type motifs 1 gene and the rs9619311 polymorphism of the tissue inhibitor of metalloproteinase-3 gene. The distributions of the genotypes and alleles between the 2 study groups (EH and NT) were compared. The main risk factors for EH were determined by using logistic regression analysis. The effects of gene-gene and gene-smoking interactions on EH were analyzed using multifactor dimensional reduction. RESULTS:The frequencies of the rs402007 GC?+?CC genotype and the C allele were significantly different between the EH and NT groups (0.68 vs 0.57, ??=?8.99, P?=?.003, odds ratio [OR]?=?1.19; 0.45 vs 0.32, ??=?22.16, P < .001, OR?=?1.38). The frequencies of the rs9619311 TC?+?CC genotype and the C allele were also significantly different between the 2 groups (0.33 vs 0.25, ??=?4.51, P?=?.04, OR?=?1.44; 0.18 vs 0.13, ??=?7.03, P?=?.01, OR?=?1.50). Logistic regression analysis suggests that the rs402007 and rs9619311 polymorphisms are independent risk factors for EH (OR?=?2.37, 1.86; P < .001, respectively). The multifactor dimensionality redundant analysis results showed that the interaction among rs402007, rs9619311, and smoking was statistically significant (P?=?.001). CONCLUSIONS:A disintegrin and metalloproteinase with thrombospondin type motifs 1 rs402007 and tissue inhibitor of metalloproteinase-3 rs9619311 polymorphisms are associated with EH in a Chinese Han population, and there was a positive interaction among rs402007, rs9619311, and smoking.

Dataset Information

Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population.

Publications

Association between polymorphisms of alpha-adducin gene and essential hypertension in Chinese population.

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