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?-Adducin gene G614T polymorphisms in essential hypertension patients with high low density lipoprotein (LDL) levels.


ABSTRACT: BACKGROUND & OBJECTIVES:The association between ?-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between ?-adducin gene G614T mutation and essential hypertension in Chinese population. METHODS:A total of 170 patients with essential hypertension (EH group) and 154 normotensive subjects (Control group) were genotyped for the cytoskeletal protein single nucleotide polymorphism G614T of the ?-adducin gene by PCR-RFLP technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), low density lipoprotein (LDL), high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP), left atrial diameter (LA DIA), left ventricular diameter (LV DIA) and other parameters were recorded in EH group. RESULTS:There was significant association between EH and ?-adducin genotypes (P<0.05). GT and TT genotypes in EH group had higher LDL levels as compared to GG carriers (P<0.05). The LDL concentration was significantly elevated in patients with GT and TT genotypes. The LDL levels also differed significantly in male patients with all the three genotypes. INTERPRETATION & CONCLUSIONS:A significant association was found between ADD1 gene G614T polymorphism and EH in Chinese patients. Further studies need to be done to confirm these findings in a large sample.

SUBMITTER: Wang L 

PROVIDER: S-EPMC4001340 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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α-Adducin gene G614T polymorphisms in essential hypertension patients with high low density lipoprotein (LDL) levels.

Wang Lifang L   Zheng Bin B   Zhao Hongguang H   Du Peng P   Sun Aihua A   Hua Kouzhen K   Gao Yuyu Y  

The Indian journal of medical research 20140201 2


<h4>Background & objectives</h4>The association between α-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population.<h4>Methods</h4>A total of 170 patients with essential hypertension (EH group) and 154 normotensive subjects (Control group) were genotyped for the cytoskeletal protein single nucleotide polymorphism G614T of  ...[more]

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