Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.
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ABSTRACT:
SUBMITTER: Kalinowska M
PROVIDER: S-EPMC3591367 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.
Kalinowska Magdalina M Bazdar Douglas A DA Lederman Michael M MM Funderburg Nicholas N Sieg Scott F SF
PloS one 20130307 3
HIV disease results in decreased IL-7 receptor expression and IL-7 responsiveness in T cells. To explore mechanisms of these deficiencies, we compared CD127 expression and IL-7 induction of P-STAT5 in T cells from HIV-infected persons with serum concentrations of cytokines (IL-7, IL-6 and IL-15), markers of microbial translocation (sCD14 and LPS), and with an indicator of oxidative stress (malondialdehyde (MDA) adducts). CD127 expression was directly related to IL-7 responsiveness in most CD8+ T ...[more]
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