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Paper spray ionization of polar analytes using non-polar solvents.


ABSTRACT: Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper.

SUBMITTER: Li A 

PROVIDER: S-EPMC3591489 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Paper spray ionization of polar analytes using non-polar solvents.

Li Anyin A   Wang He H   Ouyang Zheng Z   Cooks R Graham RG  

Chemical communications (Cambridge, England) 20110201 10


Non-polar solvents like hexane allow ionization of insoluble drugs, peptides, nucleotides and phospholipids as solids from paper. Ambient ionization is achieved simply by application of a high voltage to the wet paper. Transport and ionization mechanisms are discussed, including the possibility of field desorption from dendritic structures formed on the paper. ...[more]

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