Ontology highlight
ABSTRACT:
SUBMITTER: Ricci EP
PROVIDER: S-EPMC3592420 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Ricci Emiliano P EP Limousin Taran T Soto-Rifo Ricardo R Rubilar Paulina S PS Decimo Didier D Ohlmann Théophile T
Nucleic acids research 20121117 1
microRNAs (miRNAs) regulate gene expression at multiple levels by repressing translation, stimulating deadenylation and inducing the premature decay of target messenger RNAs (mRNAs). Although the mechanism by which miRNAs repress translation has been widely studied, the precise step targeted and the molecular insights of such repression are still evasive. Here, we have used our newly designed in vitro system, which allows to study miRNA effect on translation independently of deadenylation. By us ...[more]