Ontology highlight
ABSTRACT:
SUBMITTER: Yang WY
PROVIDER: S-EPMC3592563 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Yang Wen-Yun WY Novembre John J Eskin Eleazar E Halperin Eran E
Nature genetics 20120520 6
Characterizing genetic diversity within and between populations has broad applications in studies of human disease and evolution. We propose a new approach, spatial ancestry analysis, for the modeling of genotypes in two- or three-dimensional space. In spatial ancestry analysis (SPA), we explicitly model the spatial distribution of each SNP by assigning an allele frequency as a continuous function in geographic space. We show that the explicit modeling of the allele frequency allows individuals ...[more]