Ontology highlight
ABSTRACT:
SUBMITTER: DeGiorgio M
PROVIDER: S-EPMC4140648 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
DeGiorgio Michael M Lohmueller Kirk E KE Nielsen Rasmus R
PLoS genetics 20140821 8
While much effort has focused on detecting positive and negative directional selection in the human genome, relatively little work has been devoted to balancing selection. This lack of attention is likely due to the paucity of sophisticated methods for identifying sites under balancing selection. Here we develop two composite likelihood ratio tests for detecting balancing selection. Using simulations, we show that these methods outperform competing methods under a variety of assumptions and demo ...[more]