Ontology highlight
ABSTRACT:
SUBMITTER: Lizunov VA
PROVIDER: S-EPMC3592853 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lizunov Vladimir A VA Stenkula Karin K Troy Aaron A Cushman Samuel W SW Zimmerberg Joshua J
PloS one 20130308 3
Insulin-stimulated delivery of glucose transporter-4 (GLUT4) to the plasma membrane (PM) is the hallmark of glucose metabolism. In this study we examined insulin's effects on GLUT4 organization in PM of adipose cells by direct microscopic observation of single monomers tagged with photoswitchable fluorescent protein. In the basal state, after exocytotic delivery only a fraction of GLUT4 is dispersed into the PM as monomers, while most of the GLUT4 stays at the site of fusion and forms elongated ...[more]