Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3594035 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Wang Yuhua Y Su Hsing-Hao HH Yang Yang Y Hu Yunxia Y Zhang Lu L Blancafort Pilar P Huang Leaf L
Molecular therapy : the journal of the American Society of Gene Therapy 20121211 2
Failure of clinical trials of nonviral vector-mediated gene therapy arises primarily from either an insufficient transgene expression level or immunostimulation concerns caused by the genetic information carrier (e.g., bacteria-generated, double-stranded DNA (dsDNA)). Neither of these issues could be addressed through engineering-sophisticated gene delivery vehicles. Therefore, we propose a systemic delivery of chemically modified messenger RNA (mRNA) as an alternative to plasmid DNA (pDNA) in c ...[more]