Ontology highlight
ABSTRACT:
SUBMITTER: Strbo N
PROVIDER: S-EPMC3594107 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Strbo Natasa N Vaccari Monica M Pahwa Savita S Kolber Michael A MA Doster Melvin N MN Fisher Eva E Gonzalez Louis L Stablein Donald D Franchini Genoveffa G Podack Eckhard R ER
Journal of immunology (Baltimore, Md. : 1950) 20130211 6
Vaccine-induced protection against infection by HIV or highly pathogenic and virulent SIV strains has been limited. In a proof-of-concept study, we show that a novel vaccine approach significantly protects rhesus macaques from mucosal infection by the highly pathogenic strain SIVmac251. We vaccinated three cohorts of 12 macaques each with live, irradiated vaccine cells secreting the modified endoplasmic reticulum chaperone gp96-Ig. Cohort 1 was vaccinated with cells secreting gp96(SIV)Ig carryin ...[more]