Ontology highlight
ABSTRACT:
SUBMITTER: Talwar S
PROVIDER: S-EPMC3594286 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Talwar Sudha S Balasubramanian Sundaravadivel S Sundaramurthy Santhanalakshmi S House Reniqua R Wilusz Carol J CJ Kuppuswamy Dhandapani D D'Silva Nisha N Gillespie Marion Boyd MB Hill Elizabeth Goodwin EG Palanisamy Viswanathan V
RNA biology 20130116 2
CELF1 RNA-binding protein, otherwise called CUGBP1, associates and coordinates the degradation of GU-rich element (GRE) containing mRNA's encoding factors important for cell growth, migration and apoptosis. Although many substrates of CELF1 have been identified, the biological significance of CELF1-mediated mRNA decay remains unclear. As the processes modulated by CELF1 are frequently disrupted in cancer, we investigated the expression and role of CELF1 in oral squamous cancer cells (OSCCs). We ...[more]