Ontology highlight
ABSTRACT:
SUBMITTER: Walsh K
PROVIDER: S-EPMC3594365 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Walsh Katherine K McKinney Matthew S MS Love Cassandra C Liu Qingquan Q Fan Alice A Patel Amee A Smith Jason J Beaven Anne A Jima Dereje D DD Dave Sandeep S SS
Clinical cancer research : an official journal of the American Association for Cancer Research 20130108 5
<h4>Purpose</h4>The phosphoinositide 3-kinase (PI3K) pathway is known to play an active role in many malignancies. The role of PI3K inhibition in the treatment of lymphomas has not been fully delineated. We sought to identify a role for therapeutic PI3K inhibition across a range of B-cell lymphomas.<h4>Experimental design</h4>We selected three small molecule inhibitors to test in a panel of 60 cell lines that comprised diverse lymphoma types. We tested the selective PI3K inhibitor BKM120 and the ...[more]