Ontology highlight
ABSTRACT:
SUBMITTER: Kodack DP
PROVIDER: S-EPMC5917603 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kodack David P DP Askoxylakis Vasileios V Ferraro Gino B GB Sheng Qing Q Badeaux Mark M Goel Shom S Qi Xiaolong X Shankaraiah Ram R Cao Z Alexander ZA Ramjiawan Rakesh R RR Bezwada Divya D Patel Bhushankumar B Song Yongchul Y Costa Carlotta C Naxerova Kamila K Wong Christina S F CSF Kloepper Jonas J Das Rita R Tam Angela A Tanboon Jantima J Duda Dan G DG Miller C Ryan CR Siegel Marni B MB Anders Carey K CK Sanders Melinda M Estrada Monica V MV Schlegel Robert R Arteaga Carlos L CL Brachtel Elena E Huang Alan A Fukumura Dai D Engelman Jeffrey A JA Jain Rakesh K RK
Science translational medicine 20170501 391
Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed that brain metastases evade phosphatidylinositide 3-kinase (PI3K) inhibition despite drug accumulation in the brain lesions. In comparison to extracranial disease, we observed increased HER3 expression and phosphorylation in brain lesions. HER3 bl ...[more]