YihE kinase is a central regulator of programmed cell death in bacteria.
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ABSTRACT:
SUBMITTER: Dorsey-Oresto A
PROVIDER: S-EPMC3594398 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
YihE kinase is a central regulator of programmed cell death in bacteria.
Dorsey-Oresto Angella A Lu Tao T Mosel Michael M Wang Xiuhong X Salz Tal T Drlica Karl K Zhao Xilin X
Cell reports 20130214 2
Stress-mediated programmed cell death (PCD) in bacteria has recently attracted attention, largely because it raises novel possibilities for controlling pathogens. How PCD in bacteria is regulated to avoid population extinction due to transient, moderate stress remains a central question. Here, we report that the YihE protein kinase is a key regulator that protects Escherichia coli from antimicrobial and environmental stressors by antagonizing the MazEF toxin-antitoxin module. YihE was linked to ...[more]
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