Ontology highlight
ABSTRACT:
SUBMITTER: Akbik FV
PROVIDER: S-EPMC3594793 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Akbik Feras V FV Bhagat Sarah M SM Patel Pujan R PR Cafferty William B J WB Strittmatter Stephen M SM
Neuron 20130301 5
Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1). Through adolescence, the anatomy and plasticity of ngr1 null mice are indistinguishable from control, but suppression of turnover after age 26 days fails to occur in ngr1-/- mice. Adolescent anatomical plasticity can be restored to 1-year-old mice by cond ...[more]