Ontology highlight
ABSTRACT:
SUBMITTER: Inuzuka H
PROVIDER: S-EPMC3595190 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Inuzuka Hiroyuki H Gao Daming D Finley Lydia W S LW Yang Wen W Wan Lixin L Fukushima Hidefumi H Chin Y Rebecca YR Zhai Bo B Shaik Shavali S Lau Alan W AW Wang Zhiwei Z Gygi Steven P SP Nakayama Keiko K Teruya-Feldstein Julie J Toker Alex A Haigis Marcia C MC Pandolfi Pier Paolo PP Wei Wenyi W
Cell 20120701 1
Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with more aggressive forms of breast and prostate cancers. Here, we report that Skp2 is acetylated by p300 at K68 and K71, which is a process that can be antagonized by the SIRT3 deacetylase. Inactivation of SIRT3 leads to elevated Skp2 acetylation, which leads to increased Skp2 stability through impairment of the Cdh1-mediated ...[more]