Ontology highlight
ABSTRACT:
SUBMITTER: Paz JC
PROVIDER: S-EPMC4260582 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Paz Jose C JC Park Sangho S Phillips Naomi N Matsumura Shigenobu S Tsai Wen-Wei WW Kasper Lawryn L Brindle Paul K PK Zhang Guangtao G Zhou Ming-Ming MM Wright Peter E PE Montminy Marc M
Proceedings of the National Academy of Sciences of the United States of America 20141117 48
In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions in catecholamine signaling, where it contributes to the development of insulin resistance. Here we show that obesity promotes the CREB binding protein (CBP)-mediated acetylation of CREB at Lys136 in adipose. Under lean conditions, CREB acety ...[more]