Ontology highlight
ABSTRACT:
SUBMITTER: Chiou NT
PROVIDER: S-EPMC3595347 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20130207 5
Pre-mRNA splicing is catalyzed through the activity of the spliceosome, a dynamic enzymatic complex. Forcing aberrant interactions within the spliceosome can reduce splicing efficiency and alter splice site choice; however, it is unknown whether such alterations are naturally exploited mechanisms of splicing regulation. Here, we demonstrate that hnRNP L represses CD45 exon 4 by recruiting hnRNP A1 to a sequence upstream of the 5' splice site. Together, hnRNP L and A1 induce extended contacts bet ...[more]