Unknown

Dataset Information

0

Chemical synthesis of U1 snRNA derivatives.

ABSTRACT: U1 snRNA is an interesting biological tool for splicing correction and regulation of gene expression. However, U1 snRNA has never been chemically synthesized. In this study, the first chemical synthesis of U1snRNA and its analogues was carried out. Moreover, it was found that the binding affinity of the modified U1 snRNA with an ethylene glycol linkage to snurportin 1 (nuclear import adaptor) was as high as that of the unmodified RNA.

SUBMITTER: Ohkubo A 

PROVIDER: S-EPMC3901379 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

U1 snRNA is an interesting biological tool for splicing correction and regulation of gene expression. However, U1 snRNA has never been chemically synthesized. In this study, the first chemical synthesis of U1snRNA and its analogues was carried out. Moreover, it was found that the binding affinity of the modified U1 snRNA with an ethylene glycol linkage to snurportin 1 (nuclear import adaptor) was as high as that of the unmodified RNA. ...[more]

Similar Datasets

Unknown U1 small nuclear RNP from Trypanosoma brucei: a minimal U1 snRNA with unusual protein components.
| S-EPMC1087902 | biostudies-literature
Unknown A novel approach to describe a U1 snRNA binding site.
| S-EPMC290269 | biostudies-literature
Unknown Gene expression profiling reveals U1 snRNA regulates cancer gene expression.
| S-EPMC5762557 | biostudies-literature
Unknown Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.
| S-EPMC7141958 | biostudies-literature
Proteomics Identification of U1 snRNA associated proteins
2023-12-04 | PXD045484 | Pride
Unknown U1 snRNA directly interacts with polypyrimidine tract-binding protein during splicing repression.
| S-EPMC3931528 | biostudies-literature
Unknown Correlated motions in the U1 snRNA stem/loop 2:U1A RBD1 complex.
| S-EPMC1366707 | biostudies-literature
Unknown Architectural arrangement of the small nuclear RNA (snRNA)-activating protein complex 190 subunit (SNAP190) on U1 snRNA gene promoter DNA.
| S-EPMC3501025 | biostudies-literature
Unknown Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA.
| S-EPMC2719486 | biostudies-literature
Unknown An exon-specific U1 small nuclear RNA (snRNA) strategy to correct splicing defects.
| S-EPMC3349419 | biostudies-literature