Ontology highlight
ABSTRACT:
SUBMITTER: Fu G
PROVIDER: S-EPMC3596704 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Fu Guangbo G Tang Jialin J Wang Meilin M Qin Chao C Yan Fu F Ding Qi Q Yin Changjun C Wang Xinru X Zhang Zhengdong Z
Journal of biomedical research 20110301 2
Caspase-8 (CASP8) plays a key role in apoptosis. We examined by genotyping whether the -652 six-nucleotide insertion-deletion (6N ins/del) polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancer-free controls. Additionally, 23 prostate cancer tissues were analyzed for CASP8 mRNA expression. We found a significantly decreased prostate cancer risk for the 6N ins/del ...[more]