Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
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ABSTRACT:
SUBMITTER: Vasanthakumar A
PROVIDER: S-EPMC3596965 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Vasanthakumar Aparna A Lepore Janet B JB Zegarek Matthew H MH Kocherginsky Masha M Singh Mahi M Davis Elizabeth M EM Link Petra A PA Anastasi John J Le Beau Michelle M MM Karpf Adam R AR Godley Lucy A LA
Blood 20130111 11
The drivers of abnormal DNA methylation in human cancers include widespread aberrant splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated proteins that may act as dominant negative isoforms. To test whether reduced Dnmt3b dosage can alter tumorigenesis, we bred Dnmt3b(+/-) mice to Eµ-Myc mice, a mouse model susceptible to B-cell lymphomas. Eµ-Myc/Dnmt3b(+/-) mice showed a dramatic acceleration of lymphomagenesis, greater even than that observed in Eµ-Myc mice that ex ...[more]
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