Short communication: genetic variations of SLC2A9 in relation to Parkinson's disease.

ABSTRACT: BACKGROUND:Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson's disease (PD) and slower disease progression. Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout. METHODS:We conducted a case-control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European ancestry. Odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models, adjusting for age, sex, smoking and caffeine consumption. RESULTS:These SNPs were all in linkage disequilibrium (R2?>?0.7). None of them were associated with PD risk. Among women, however, there was a suggestion that the presence of the minor allele of one SNP (rs7442295) was related to a small increase in PD risk [OR (95% CI)?=?1.48 (1.01-2.16)]. CONCLUSION:This study provides little support for genetic variations of SLC2A9 and PD risk.

SUBMITTER: Gao J 

PROVIDER: S-EPMC3598344 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature