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ABSTRACT: Background
Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson's disease (PD) and slower disease progression. Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout.Methods
We conducted a case-control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European ancestry. Odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models, adjusting for age, sex, smoking and caffeine consumption.Results
These SNPs were all in linkage disequilibrium (R2 > 0.7). None of them were associated with PD risk. Among women, however, there was a suggestion that the presence of the minor allele of one SNP (rs7442295) was related to a small increase in PD risk [OR (95% CI) = 1.48 (1.01-2.16)].Conclusion
This study provides little support for genetic variations of SLC2A9 and PD risk.
SUBMITTER: Gao J
PROVIDER: S-EPMC3598344 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Gao Jianjun J Xu Hong H Huang Xuemei X Chen Honglei H
Translational neurodegeneration 20130219 1
<h4>Background</h4>Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson's disease (PD) and slower disease progression. Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout.<h4>Methods</h4>We conducted a case-control study to examine twelve tag SNPs of the SLC2A9 ...[more]