Ontology highlight
ABSTRACT:
SUBMITTER: Balasubramaniam D
PROVIDER: S-EPMC3600394 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20121022 6
Amide hydrogen/deuterium exchange detected by mass spectrometry (HXMS) is seeing wider use for the identification of intrinsically disordered parts of proteins. In this review, we discuss examples of how discovery of intrinsically disordered regions and their removal can aid in structure determination, biopharmaceutical quality control, the characterization of how post-translational modifications affect weak structuring of disordered regions, the study of coupled folding and binding, and the cha ...[more]