Ontology highlight
ABSTRACT:
SUBMITTER: Dunphy JL
PROVIDER: S-EPMC3600433 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Dunphy Jillian L JL Moravec Radim R Ly Kim K Lasell Troy K TK Melancon Paul P Casanova James E JE
Current biology : CB 20060201 3
The small GTPase Arf6 has been shown to regulate the post-endocytic trafficking of a subset of membrane proteins, including beta1 integrins, and inhibition of Arf6 function impairs both cell adhesion and motility. The activity of Arf GTPases is regulated by a large family of guanine nucleotide exchange factors (GEFs). Arf-GEP100/BRAG2 is a GEF with reported specificity for Arf6 in vitro, but it is otherwise poorly characterized. Here we report that BRAG2 exists in two ubiquitously expressed isof ...[more]