Ontology highlight
ABSTRACT:
SUBMITTER: Huang IH
PROVIDER: S-EPMC4179489 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Huang I-Husan IH Hsiao Cheng-Te CT Wu Jui-Chung JC Shen Rong-Fong RF Liu Ching-Yi CY Wang Yang-Kao YK Chen Yu-Chen YC Huang Chi-Ming CM del Álamo Juan C JC Chang Zee-Fen ZF Tang Ming-Jer MJ Khoo Kay-Hooi KH Kuo Jean-Cheng JC
Journal of cell science 20140808 Pt 19
Focal adhesions (FAs) undergo maturation that culminates in size and composition changes that modulate adhesion, cytoskeleton remodeling and differentiation. Although it is well recognized that stimuli for osteogenesis of mesenchymal stem cells (MSCs) drive FA maturation, actin organization and stress fiber polarization, the extent to which FA-mediated signals regulated by the FA protein composition specifies MSC commitment remains largely unknown. Here, we demonstrate that, upon dexamethasone ( ...[more]