Molecular characteristics of cancer stem-like cells derived from human breast cancer cells.
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ABSTRACT:
SUBMITTER: Yoo YD
PROVIDER: S-EPMC3600631 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Molecular characteristics of cancer stem-like cells derived from human breast cancer cells.
Yoo Young Dong YD Han Dong Hoon DH Jang Jun Min JM Zakrzewska Adriana A Kim Seog-Young SY Choi Cheol Yong CY Lee Yong Jun YJ Kwon Yong Tae YT
Anticancer research 20130301 3
We characterized the cellular properties of cancer stem-like cells (CSLCs) isolated from immortalized MDA-MB453 human breast cancer cells in culture. We showed that although the expression of Octamer-binding transcription factor-4 (OCT4) correlates to stemness in these CSLCs, OCT4 knockdown does not induce their differentiation. Our results suggest that the differentiation program in MDA-MB453 CSLCs is blocked at a step upstream of the transcription of the OCT4 promoter, allowing CSLCs to mainta ...[more]
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