White matter tract signatures of the progressive aphasias.
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ABSTRACT:
SUBMITTER: Mahoney CJ
PROVIDER: S-EPMC3601331 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
White matter tract signatures of the progressive aphasias.
Mahoney Colin J CJ Malone Ian B IB Ridgway Gerard R GR Buckley Aisling H AH Downey Laura E LE Golden Hannah L HL Ryan Natalie S NS Ourselin Sebastien S Schott Jonathan M JM Rossor Martin N MN Fox Nick C NC Warren Jason D JD
Neurobiology of aging 20130109 6
The primary progressive aphasias (PPA) are a heterogeneous group of language-led neurodegenerative diseases resulting from large-scale brain network degeneration. White matter (WM) pathways bind networks together, and might therefore hold information about PPA pathogenesis. Here we used diffusion tensor imaging and tract-based spatial statistics to compare WM tract changes between PPA syndromes and with respect to Alzheimer's disease and healthy controls in 33 patients with PPA (13 nonfluent/agr ...[more]
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