Ontology highlight
ABSTRACT:
SUBMITTER: Xia WF
PROVIDER: S-EPMC3601351 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Xia Wen-Fang WF Tang Fu-Lei FL Xiong Lei L Xiong Shan S Jung Ji-Ung JU Lee Dae-Hoon DH Li Xing-Sheng XS Feng Xu X Mei Lin L Xiong Wen-Cheng WC
The Journal of cell biology 20130301 6
Receptor activator of NF-κB (RANK) plays a critical role in osteoclastogenesis, an essential process for the initiation of bone remodeling to maintain healthy bone mass and structure. Although the signaling and function of RANK have been investigated extensively, much less is known about the negative regulatory mechanisms of its signaling. We demonstrate in this paper that RANK trafficking, signaling, and function are regulated by VPS35, a major component of the retromer essential for selective ...[more]