Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC6307845 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Wang Qingqing Q Yao Lingya L Xu Ke K Jin Haiming H Chen Kai K Wang Ziyi Z Liu Qian Q Cao Zhen Z Kenny Jacob J Liu Yuhao Y Tickner Jennifer J Xu Huazi H Xu Jiake J
Journal of cellular and molecular medicine 20181019 1
Osteoporosis is the most common osteolytic disease characterized by excessive osteoclast formation and resultant bone loss, which afflicts millions of patients around the world. Madecassoside (MA), isolated from Centella asiatica, was reported to have anti-inflammatory and antioxidant activities, but its role in osteoporosis treatment has not yet been confirmed. In our study, MA was found to have an inhibitory effect on the RANKL-induced formation and function of OCs in a dose-dependent manner w ...[more]