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Bacterial cell division regulation by Ser/Thr kinases: a structural perspective.

ABSTRACT: Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data.

SUBMITTER: Ruggiero A

PROVIDER: S-EPMC3601408 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Bacterial cell division regulation by Ser/Thr kinases: a structural perspective.

Ruggiero Alessia A De Simone Paola P Smaldone Giovanni G Squeglia Flavia F Berisio Rita R

Current protein & peptide science 20121201 8

Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphory ...[more]

PMID: 23305362

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