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Ser/Thr protein phosphatases in fungi: structure, regulation and function.

ABSTRACT: Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukar-yotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we pre-sent the members of this family in S. cerevisiae and other fungal species, and review the most recent findings concerning their regu-lation and the roles they play in the most diverse aspects of cell biology.

SUBMITTER: Arino J

PROVIDER: S-EPMC6506691 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Ser/Thr protein phosphatases in fungi: structure, regulation and function.

Ariño Joaquín J Velázquez Diego D Casamayor Antonio A

Microbial cell (Graz, Austria) 20190424 5

Reversible phospho-dephosphorylation of proteins is a major mechanism for the control of cellular functions. By large, Ser and Thr are the most frequently residues phosphorylated in eukar-yotes. Removal of phosphate from these amino acids is catalyzed by a large family of well-conserved enzymes, collectively called Ser/Thr protein phosphatases. The activity of these enzymes has an enormous impact on cellular functioning. In this work we pre-sent the members of this family in <i>S. cerevisiae</i> ...[more]

PMID: 31114794

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