Ontology highlight
ABSTRACT:
SUBMITTER: Yuan J
PROVIDER: S-EPMC3601832 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Yuan Jingsong J Ghosal Gargi G Chen Junjie J
Molecular cell 20120614 3
Proteins with annealing activity are newly identified ATP-dependent motors that can rewind RPA-coated complementary single-stranded DNA bubbles. AH2 (annealing helicase 2, also named as ZRANB3) is the second protein with annealing activity, the function of which is still unknown. Here, we report that AH2 is recruited to stalled replication forks and that cells depleted of AH2 are hypersensitive to replication stresses. Furthermore, AH2 binds to PCNA, which is crucial for its function at stalled ...[more]