Ontology highlight
ABSTRACT:
SUBMITTER: Jensen RB
PROVIDER: S-EPMC3602134 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Jensen Ryan B RB Ozes Ali A Kim Taeho T Estep Allison A Kowalczykowski Stephen C SC
DNA repair 20130204 4
Homologous recombination plays an important role in the high-fidelity repair of DNA double-strand breaks. A central player in this process, RAD51, polymerizes onto single-stranded DNA and searches for homology in a duplex donor DNA molecule, usually the sister chromatid. Homologous recombination is a highly regulated event in mammalian cells: some proteins have direct enzymatic functions, others mediate or overcome rate-limiting steps in the process, and still others signal cell cycle arrest to ...[more]