Ontology highlight
ABSTRACT:
SUBMITTER: Rosenbaum JC
PROVIDER: S-EPMC6683157 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature communications 20190805 1
Accurate DNA replication is essential for genomic stability and cancer prevention. Homologous recombination is important for high-fidelity DNA damage tolerance during replication. How the homologous recombination machinery is recruited to replication intermediates is unknown. Here, we provide evidence that a Rad51 paralog-containing complex, the budding yeast Shu complex, directly recognizes and enables tolerance of predominantly lagging strand abasic sites. We show that the Shu complex becomes ...[more]