Effect of a high-protein diet on kidney function in healthy adults: results from the OmniHeart trial.

ABSTRACT:

Background

Consumption of a diet high in protein can cause glomerular hyperfiltration, a potentially maladaptive response, which may accelerate the progression of kidney disease.

Study design

An ancillary study of the OmniHeart trial, a randomized 3-period crossover feeding trial testing the effects of partial replacement of carbohydrate with protein on kidney function.

Setting & participants

Healthy adults (N=164) with prehypertension or stage 1 hypertension at a community-based research clinic with a metabolic kitchen.

Intervention

Participants were fed each of 3 diets for 6 weeks. Feeding periods were separated by a 2- to 4-week washout period. Weight was held constant on each diet. The 3 diets emphasized carbohydrate, protein, or unsaturated fat; dietary pr

SUBMITTER: Juraschek SP 

PROVIDER: S-EPMC3602135 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature