Mapping repetition suppression of the P50 evoked response to the human cerebral cortex.

ABSTRACT:

Objective

The cerebral network subserving repetition suppression (RS) of the P50 auditory evoked response as observed using paired-identical-stimulus (S1-S2) paradigms is not well-described.

Methods

We analyzed S1-S2 data from electrodes placed on the cortices of 64 epilepsy patients. We identified regions with maximal amplitude responses to S1 (i.e., stimulus registration), regions with maximal suppression of responses to S2 relative to S1 (i.e., RS), and regions with no or minimal RS 30-80 ms post stimulation.

Results

Several temporal, parietal and cingulate area regions were shown to have significant initial registration activity (i.e., strong P50 response to S1). Moreover, prefrontal, cingulate, and parietal lobe regions not previously proposed to be part of the P

SUBMITTER: Boutros NN 

PROVIDER: S-EPMC3602141 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature