Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3602223 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Zhang Ying Y Farenholtz Kaitlyn E KE Yang Yanzhi Y Guessous Fadila F Dipierro Charles G CG Calvert Valerie S VS Deng Jianghong J Schiff David D Xin Wenjun W Lee Jae K JK Purow Benjamin B Christensen James J Petricoin Emanuel E Abounader Roger R
Clinical cancer research : an official journal of the American Association for Cancer Research 20130205 6
<h4>Purpose</h4>The receptor tyrosine kinase (RTK) c-MET and its ligand hepatocyte growth factor (HGF) are deregulated and promote malignancy in cancer and brain tumors. Consequently, clinically applicable c-MET inhibitors have been developed. The purpose of this study was to investigate the not-well-known molecular determinants that predict responsiveness to c-MET inhibitors and to explore new strategies for improving inhibitor efficacy in brain tumors.<h4>Experimental design</h4>We investigate ...[more]