Ontology highlight
ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC3603369 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Yang Da D Sun Yan Y Hu Limei L Zheng Hong H Ji Ping P Pecot Chad V CV Zhao Yanrui Y Reynolds Sheila S Cheng Hanyin H Rupaimoole Rajesha R Cogdell David D Nykter Matti M Broaddus Russell R Rodriguez-Aguayo Cristian C Lopez-Berestein Gabriel G Liu Jinsong J Shmulevich Ilya I Sood Anil K AK Chen Kexin K Zhang Wei W
Cancer cell 20130201 2
Integrated genomic analyses revealed a miRNA-regulatory network that further defined a robust integrated mesenchymal subtype associated with poor overall survival in 459 cases of serous ovarian cancer (OvCa) from The Cancer Genome Atlas and 560 cases from independent cohorts. Eight key miRNAs, including miR-506, miR-141, and miR-200a, were predicted to regulate 89% of the targets in this network. Follow-up functional experiments illustrate that miR-506 augmented E-cadherin expression, inhibited ...[more]