Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing.
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ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC4751494 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Integrated microRNA-mRNA analyses reveal OPLL specific microRNA regulatory network using high-throughput sequencing.
Xu Chen C Chen Yu Y Zhang Hao H Chen Yuanyuan Y Shen Xiaolong X Shi Changgui C Liu Yang Y Yuan Wen W
Scientific reports 20160212
Ossification of the posterior longitudinal ligament (OPLL) is a genetic disorder which involves pathological heterotopic ossification of the spinal ligaments. Although studies have identified several genes that correlated with OPLL, the underlying regulation network is far from clear. Through small RNA sequencing, we compared the microRNA expressions of primary posterior longitudinal ligament cells form OPLL patients with normal patients (PLL) and identified 218 dysregulated miRNAs (FDR < 0.01). ...[more]
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