Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis.

ABSTRACT:

Rationale

Idiopathic pulmonary fibrosis (IPF) is a disease of progressive lung fibrosis with a high mortality rate. In organ repair and remodeling, epigenetic events are important. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and can target epigenetic molecules important in DNA methylation. The miR-17~92 miRNA cluster is critical for lung development and lung epithelial cell homeostasis and is predicted to target fibrotic genes and DNA methyltransferase (DNMT)-1 expression.

Objectives

We investigated the miR-17~92 cluster expression and its role in regulating DNA methylation events in IPF lung tissue.

Methods

Expression and DNA methylation patterns of miR-17~92 were determined in human IPF lung tissue and fibroblasts and fibrotic mouse lung tissu

SUBMITTER: Dakhlallah D 

PROVIDER: S-EPMC3603596 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature