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Limited miR-17-92 overexpression drives hematologic malignancies.

ABSTRACT: The overexpression of microRNA cluster miR-17-92 has been implicated in development of solid tumors and hematological malignancies. The role of miR-17-92 in lymphomagenesis has been extensively investigated; however, because of the developmental defects caused by miR-17-92 dysregulation, its ability to drive tumorigenesis has remained undetermined until recently. Here we demonstrate that overexpression of miR-17-92 in a limited number of hematopoietic cells is sufficient to cause B cell malignancies. In sum, our study provides a novel and physiologically relevant model that exposes the potent ability of miR-17-92 to act as a driver of tumorigenesis.

SUBMITTER: Danielson LS

PROVIDER: S-EPMC4376677 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Limited miR-17-92 overexpression drives hematologic malignancies.

Danielson Laura S LS Reavie Linsey L Coussens Marc M Davalos Veronica V Castillo-Martin Mireia M Guijarro Maria V MV Coffre Maryaline M Cordon-Cardo Carlos C Aifantis Iannis I Ibrahim Sherif S Liu Cynthia C Koralov Sergei B SB Hernando Eva E

Leukemia research 20141210 3

The overexpression of microRNA cluster miR-17-92 has been implicated in development of solid tumors and hematological malignancies. The role of miR-17-92 in lymphomagenesis has been extensively investigated; however, because of the developmental defects caused by miR-17-92 dysregulation, its ability to drive tumorigenesis has remained undetermined until recently. Here we demonstrate that overexpression of miR-17-92 in a limited number of hematopoietic cells is sufficient to cause B cell malignan ...[more]

PMID: 25597017

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