Activating somatic FGFR2 mutations in breast cancer.
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ABSTRACT:
SUBMITTER: Reintjes N
PROVIDER: S-EPMC3603931 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Activating somatic FGFR2 mutations in breast cancer.
Reintjes Nadine N Li Yun Y Becker Alexandra A Rohmann Edyta E Schmutzler Rita R Wollnik Bernd B
PloS one 20130320 3
It is known that FGFR2 gene variations confer a risk for breast cancer. FGFR2 and FGF10, the main ligand of FGFR2, are both overexpressed in 5-10% of breast tumors. In our study, we sequenced the most important coding regions of FGFR2 in somatic tumor tissue of 140 sporadic breast cancer patients and performed MLPA analysis to detect copy number variations in FGFR2 and FGF10. We identified one somatic heterozygous missense mutation, p.K660N (c.1980G>C), within the tyrosine kinase domain of FGFR2 ...[more]
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