Ontology highlight
ABSTRACT:
SUBMITTER: Gramberg T
PROVIDER: S-EPMC3605129 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Gramberg Thomas T Kahle Tanja T Bloch Nicolin N Wittmann Sabine S Müllers Erik E Daddacha Waaqo W Hofmann Henning H Kim Baek B Lindemann Dirk D Landau Nathaniel R NR
Retrovirology 20130305
<h4>Background</h4>SAMHD1 is a triphosphohydrolase that restricts the replication of HIV-1 and SIV in myeloid cells. In macrophages and dendritic cells, SAMHD1 restricts virus replication by diminishing the deoxynucleotide triphosphate pool to a level below that which supports lentiviral reverse transcription. HIV-2 and related SIVs encode the accessory protein Vpx to induce the proteasomal degradation of SAMHD1 following virus entry. While SAMHD1 has been shown to restrict HIV-1 and SIV, the br ...[more]