Ontology highlight
ABSTRACT:
SUBMITTER: Goult BT
PROVIDER: S-EPMC3605642 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Goult Benjamin T BT Zacharchenko Thomas T Bate Neil N Tsang Ricky R Hey Fiona F Gingras Alexandre R AR Elliott Paul R PR Roberts Gordon C K GCK Ballestrem Christoph C Critchley David R DR Barsukov Igor L IL
The Journal of biological chemistry 20130206 12
Talin activates integrins, couples them to F-actin, and recruits vinculin to focal adhesions (FAs). Here, we report the structural characterization of the talin rod: 13 helical bundles (R1-R13) organized into a compact cluster of four-helix bundles (R2-R4) within a linear chain of five-helix bundles. Nine of the bundles contain vinculin-binding sites (VBS); R2R3 are atypical, with each containing two VBS. Talin R2R3 also binds synergistically to RIAM, a Rap1 effector involved in integrin activat ...[more]