Ontology highlight
ABSTRACT:
SUBMITTER: Schafer IB
PROVIDER: S-EPMC3605791 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Schäfer Ingmar B IB Hesketh Geoffrey G GG Bright Nicholas A NA Gray Sally R SR Pryor Paul R PR Evans Philip R PR Luzio J Paul JP Owen David J DJ
Nature structural & molecular biology 20121028 12
SNAREs provide energy and specificity to membrane fusion events. Fusogenic trans-SNARE complexes are assembled from glutamine-contributing SNAREs (Q-SNAREs) embedded in one membrane and an arginine-contributing SNARE (R-SNARE) embedded in the other. Regulation of membrane fusion events is crucial for intracellular trafficking. We identify the endosomal protein Varp as an R-SNARE-binding regulator of SNARE complex formation. Varp colocalizes with and binds to VAMP7, an R-SNARE that is involved in ...[more]