Ontology highlight
ABSTRACT:
SUBMITTER: Yatsu A
PROVIDER: S-EPMC4359733 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Yatsu Ayaka A Shimada Hikaru H Ohbayashi Norihiko N Fukuda Mitsunori M
Biology open 20150206 3
Varp (VPS9-ankyrin repeat protein) was originally identified as an activator of small GTPase Rab21 through its VPS9 domain, but it has subsequently been shown to function as a Rab32/38 effector through its first ANKR1 domain. Although these functions of Varp are important for melanogenesis, Varp contains a second ANKR2 domain, whose function remained completely unknown. Here we identified Rab40C, an atypical Rab containing a SOCS box that recruits a ubiquitin ligase complex, as a novel ANKR2-bin ...[more]