Ontology highlight
ABSTRACT:
SUBMITTER: Yestrepsky BD
PROVIDER: S-EPMC3605901 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20130201 7
Resistance to antibiotics is an increasingly dire threat to human health that warrants the development of new modes of treating infection. We recently identified 1 (CCG-2979) as an inhibitor of the expression of streptokinase, a critical virulence factor in Group A Streptococcus that endows blood-borne bacteria with fibrinolytic capabilities. In this report, we describe the synthesis and biological evaluation of a series of novel 5,6-dihydrobenzo[h]quinazolin-4(3H)-one analogs of 1 undertaken wi ...[more]