Azo-propofols: photochromic potentiators of GABA(A) receptors.

ABSTRACT: Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to ?-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system. Azobenzene derivatives of propofol, such as compound 1 (see scheme), increase GABA-induced currents in the dark form and lose this property upon light exposure and thus function as photochromic potentiators. Compound 1 can be employed as a light-dependent general anesthetic in translucent tadpoles.

SUBMITTER: Stein M 

PROVIDER: S-EPMC3606271 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature