Azo-propofols: photochromic potentiators of GABA(A) receptors.
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ABSTRACT:
SUBMITTER: Stein M
PROVIDER: S-EPMC3606271 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
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Azo-propofols: photochromic potentiators of GABA(A) receptors.
Stein Marco M Middendorp Simon J SJ Carta Valentina V Pejo Ervin E Raines Douglas E DE Forman Stuart A SA Sigel Erwin E Trauner Dirk D
Angewandte Chemie (International ed. in English) 20120911 42
Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system. Azobenzene derivatives of propofol, such as compound 1 (see scheme), increase GABA-induced currents in the dark form and lose this property upon light exposure and thus function as photochromic potentiators. Compound 1 can be employed as a light-dependent general anesthetic in translucent tadpo ...[more]
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